4'-Iodo-4'-Deoxydoxorubicin

Preferred Label : 4'-Iodo-4'-Deoxydoxorubicin;

NCIt synonyms : Iodo-Doxorubicin; 4'-Deoxy-4'-Iododoxorubicin; IDOX; 4 Iodo-4 Deoxydoxorubicin;

NCIt related terms : iododoxorubicin;

NCIt definition : An iodinated doxorubicin analogue with antiamyloid activity. 4'-Iodo-4'-deoxydoxorubicin (IDOX) binds with high affinity to five types of natural amyloid fibrils including immunoglobulin light chains, amyloid A, transthyretin (methionine-30 variant), beta-protein (Alzheimer), and beta2-microglobulin. This agent may inhibit fibril growth, increasing the solubility of amyloid tissue deposits and facilitating their clearance. IDOX has also been shown to insulin amyloid fibrillogenesis in vitro.;

Alternative definition : NCI-GLOSS: A substance that is being studied as a treatment for cancer, and for primary systemic amyloidosis (a disease in which proteins are deposited in specific organs). It belongs to the family of drugs called anthracycline analogues.;

UNII : 65JH75I9JX;

CAS number : 83997-75-5;

NSC code : 378901;

ChEBI ID : CHEBI:47897;

Codes from synonyms : CDR0000045340;

Details

Origin ID

C971;

UMLS CUI

C0047758;

Currated CISMeF NLP mapping
- 4'-deoxy-4'-iododoxorubicin [MeSH concept]
- 4'-deoxy-4'-iododoxorubicin [MeSH Supplementary Concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 4'-deoxy-4'-iododoxorubicin [MeSH concept]
- 4'-deoxy-4'-iododoxorubicin [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Amyloid Fibril Interaction [NCIt concept]
- DNA Intercalation [NCIt concept]
chemical_or_drug_has_physiologic_effect
- DNA Replication Inhibition [NCIt concept]
- DNA Strand Break [NCIt concept]
- Inhibition of Amyloidogenesis [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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