Preferred Label : Anti-PD-1 Fusion Protein AMP-224;
NCIt related terms : AMP-224;
NCIt definition : A recombinant B7-DC Fc-fusion protein composed of the extracellular domain of the
PD-1 ligand programmed cell death ligand 2 (PD-L2, B7-DC) and the Fc region of human
immunoglobulin (Ig) G1, with potential immune checkpoint inhibitory and antineoplastic
activities. Anti-PD-1 fusion protein AMP-224 specifically binds to PD-1 on chronically
stimulated T-cells and reduces their proliferation. This may restore immune function
and may result in the activation of cytotoxic T-cells and cell-mediated immune responses
against tumor cells. PD-1, a transmembrane protein of Ig superfamily and inhibitor
receptor expressed on activated T-cells, negatively regulates T-cell activation and
effector function when activated by its ligands, and plays an important role in tumor
evasion from host immunity. AMP-224 does not bind normal activated T-cells.;
UNII : SKF3JJJ5QA;
CAS number : 1422184-00-6;
Molecule name : AMP-224;
NCI Metathesaurus CUI : CL429646;
Origin ID : C97039;
UMLS CUI : C3273207;
Semantic type(s)
- concept_is_in_subset
- has_target
