Preferred Label : Eribulin;
NCIt synonyms : 2-(3-Amino-2-hydroxypropyl)hexacosahydro-3-methoxy-26-methyl-20,27-bis(methylene)11,15-18,21-24,28-triepoxy-7,9-ethano-12,15-methano-9H,15H-furo(3,2-i)furo(2',3'-5,6)pyrano(4,3-b)(1,4)dioxacyclopentacosin-5-(4H)-one;
NCIt definition : An analogue of halichondrin B, a substance derived from a marine sponge (Lissodendoryx
sp.) with antineoplastic activity. Eribulin binds to the vinca domain of tubulin and
inhibits the polymerization of tubulin and the assembly of microtubules, resulting
in inhibition of mitotic spindle assembly, induction of cell cycle arrest at G2/M
phase, and, potentially, tumor regression.;
UNII : LR24G6354G;
InChIKey : UFNVPOGXISZXJD-JBQZKEIOSA-N;
CAS number : 253128-41-5;
Molecule name : ER-086526; ER 086526; E-7389; E 7389;
Chemical formula : C40H59NO11;
ChEBI ID : CHEBI:63587;
Codes from synonyms : 197;
Origin ID : C96748;
UMLS CUI : C2350866;
CISMeF manual mappings
- Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_salt_form
- has_target
- is_free_acid_or_base_form_of
