Cordycepin Triphosphate

Preferred Label : Cordycepin Triphosphate;

NCIt synonyms : 3'-Deoxyadenosine-5'-(tetrahydrogen triphosphate); Cordycepin-5'-triphosphate;

NCIt definition : The triphosphate salt of cordycepin, a purine nucleoside antimetabolite and antibiotic isolated from the fungus Cordyceps militaris with potential antineoplastic, antioxidant, and anti-inflammatory activities. Cordycepin is an inhibitor of polyadenylation, activates AMP-activated protein kinase (AMPK), and reduces mammalian target of rapamycin (mTOR) signaling, which may result in both the induction of tumor cell apoptosis and a decrease in tumor cell proliferation. mTOR, a serine/threonine kinase belonging to the phosphatidylinositol 3-kinase (PI3K)-related kinase (PIKK) family, plays an important role in the PI3K/AKT/mTOR signaling pathway that regulates cell growth and proliferation, and its expression or activity is frequently dysregulated in human cancers.;

UNII : 59P84ZU54H;

InChIKey : NLIHPCYXRYQPSD-BAJZRUMYSA-N;

CAS number : 73-04-1;

ChEBI ID : CHEBI:52316;

Details

Origin ID

C967;

UMLS CUI

C0046803;

Automatic exact mappings (from CISMeF team)
- 3'-deoxyadenosine 5'-triphosphate [MeSH concept]
Currated CISMeF NLP mapping
- 3'-deoxyadenosine 5'-triphosphate [MeSH Supplementary Concept]
Semantic type(s)
- Antibiotic [UMLS semantic type]
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
UMLS correspondences (same concept)
- 3'-deoxyadenosine 5'-triphosphate [MeSH concept]
- 3'-deoxyadenosine 5'-triphosphate [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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