Cordycepin - CISMeF

Preferred Label : Cordycepin;

NCIt synonyms : Cordycepine; 3'-dA-CE Phosphoramidite; 9-Cordyceposidoadenine; Kordicepin; COR; 3-dAdenosine; 3'-Deoxyadenosine;

NCIt definition : A purine nucleoside antimetabolite and antibiotic isolated from the fungus Cordyceps militaris with potential antineoplastic, antioxidant, and anti-inflammatory activities. Cordycepin is an inhibitor of polyadenylation, activates AMP-activated protein kinase (AMPK) and reduces mammalian target of rapamycin (mTOR) signaling, which may result in both the induction of tumor cell apoptosis and a decrease in tumor cell proliferation. mTOR, a serine/threonine kinase belonging to the phosphatidylinositol 3-kinase (PI3K)-related kinase (PIKK) family, plays an important role in the PI3K/AKT/mTOR signaling pathway that regulates cell growth and proliferation, and its expression or activity is frequently dysregulated in human cancers.;

Alternative definition : NCI-GLOSS: An anticancer drug that belongs to a family of drugs called antitumor antibiotics.;

UNII : GZ8VF4M2J8;

InChIKey : OFEZSBMBBKLLBJ-BAJZRUMYSA-N;

CAS number : 73-03-0;

NSC code : 627047; 401022; 63984;

ChEBI ID : CHEBI:29014;

Codes from synonyms : NSC0063984; CDR0000045536;

Details

Origin ID

C1057;

UMLS CUI

C0056331;

Automatic exact mappings (from CISMeF team)
- 2'-deoxyadenosine [MeSH concept]
- 2'-deoxyadenosine [MeSH Supplementary Concept]
- 2'-deoxyadenosine [Substance BNPC]
- 5'-deoxyadenosine [MeSH concept]
- 5'-deoxyadenosine [MeSH Supplementary Concept]
- Deoxyadenosine (substance) [SNOMED CT concept]
- Heart [LOINC System]
- corynebacterium pyogenes [MeSH Descriptor]
- deoxyadenosines [MeSH Descriptor]
- deoxyadenosines [MeSH concept]
Currated CISMeF NLP mapping
- 3'-deoxyadenosine [Substance BNPC]
- 3'-deoxyadenosine (substance) [SNOMED CT concept]
- Product containing 3'-deoxyadenosine (medicinal product) [SNOMED CT concept]
- cordycepin [MeSH concept]
- cordycepin [MeSH Supplementary Concept]
False automatic mappings
- Joubert syndrome with oculorenal defect [ORDO Disease]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 3'-deoxyadenosine [Substance BNPC]
- 3'-deoxyadenosine (substance) [SNOMED CT concept]
- Product containing 3'-deoxyadenosine (medicinal product) [SNOMED CT concept]
- cordycepin [MeSH concept]
- cordycepin [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Nucleoside Analogue Incorporation [NCIt concept]
chemical_or_drug_has_physiologic_effect
- RNA Synthesis Inhibition [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Cordycepin/Pentostatin [NCIt concept]

Keyword's position in hierarchy(ies) :

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