Preferred Label : Camostat Mesylate;
NCIt synonyms : Camostat Monomethanesulfonate; N,N-Dimethylcarbamoylmethyl 4-(4-guanidinobenzoyloxy)phenylacetate Methanesulfonate; Camostat Mesilate;
NCIt definition : The mesylate salt form of camostat, an orally bioavailable, synthetic serine protease
inhibitor, with anti-inflammatory, antifibrotic, and potential antiviral activities.
Upon oral administration, camostat and its metabolite 4-(4-guanidinobenzoyloxyl)phenyl
acetic acid (FOY 251) inhibit the activities of a variety of proteases, including
trypsin, kallikrein, thrombin and plasmin, and C1r- and C1 esterases. Although the
mechanism of action of camostat is not fully understood, trypsinogen activation in
the pancreas is known to be a trigger reaction in the development of pancreatitis.
Camostat blocks the activation of trypsinogen to trypsin and the inflammatory cascade
that follows. Camostat may also suppress the expression of the cytokines interleukin-1beta
(IL-1b), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-a) and transforming
growth factor-beta (TGF-beta), along with alpha-smooth muscle actin (alpha-SMA). This
reduces inflammation and fibrosis of the pancreas. In addition, camostat may inhibit
the activity of transmembrane protease, serine 2 (TMPRSS2), a host cell serine protease
that mediates viral cell entry for influenza virus and coronavirus, thereby inhibiting
viral infection and replication.;
UNII : 451M50A1EQ;
InChIKey : FSEKIHNIDBATFG-UHFFFAOYSA-N;
CAS number : 59721-29-8;
Drug name : Foipan;
Molecule name : FOY 305; FOY-305; DWJ1248;
Chemical formula : C20H22N4O5.CH4O3S;
ChEBI ID : CHEBI:31347;
PubMed : 19145783;
Origin ID : C96364;
UMLS CUI : C0108225;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
