Preferred Label : Camostat;
NCIt definition : An orally bioavailable, synthetic serine protease inhibitor, with anti-inflammatory,
antifibrotic, and potential antiviral activities. Upon oral administration, camostat
and its metabolite 4-(4-guanidinobenzoyloxyl)phenyl acetic acid (FOY 251) inhibit
the activities of a variety of proteases, including trypsin, kallikrein, thrombin
and plasmin, and C1r- and C1 esterases. Although the mechanism of action of camostat
is not fully understood, trypsinogen activation in the pancreas is known to be a trigger
reaction in the development of pancreatitis. Camostat blocks the activation of trypsinogen
to trypsin and the inflammatory cascade that follows. Camostat may also suppress the
expression of the cytokines interleukin-1beta (IL-1b), interleukin-6 (IL-6), tumor
necrosis factor-alpha (TNF-a) and transforming growth factor-beta (TGF-beta), along
with alpha-smooth muscle actin (alpha-SMA). This reduces inflammation and fibrosis
of the pancreas. In addition, camostat may inhibit the activity of transmembrane protease,
serine 2 (TMPRSS2), a host cell serine protease that mediates viral cell entry for
influenza virus and coronavirus, thereby inhibiting viral infection and replication.;
UNII : 0FD207WKDU;
InChIKey : XASIMHXSUQUHLV-UHFFFAOYSA-N;
CAS number : 59721-28-7;
Chemical formula : C20H22N4O5;
Origin ID : C73213;
UMLS CUI : C0129975;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_salt_form
- is_free_acid_or_base_form_of
