Preferred Label : Nafamostat Mesylate;
NCIt synonyms : Nafamostat Dimethanesulfonate; Benzoic acid, 4-((aminoiminomethyl)amino)-, 6-(aminoiminomethyl)-2-naphthalenyl ester,
Dimethanesulfonate; 6-Amidino-2-naphthyl 4-guanidinobenzoate Dimethanesulfonate; Nafamostat Mesilate;
NCIt definition : The mesylate salt form of nafamostat, a broad-spectrum, synthetic serine protease
inhibitor, with anticoagulant, anti-inflammatory, mucus clearing, and potential antiviral
activities. Upon administration, nafamostat inhibits the activities of a variety of
proteases, including thrombin, plasmin, kallikrein, trypsin, and Cl esterase in the
complement system, and factors VIIa, Xa, and XIIa in the coagulation system. Although
the mechanism of action of nafamostat is not fully understood, trypsinogen activation
in the pancreas is known to be a trigger reaction in the development of pancreatitis.
Nafamostat blocks the activation of trypsinogen to trypsin and the inflammatory cascade
that follows. Nafamostat may also decrease epithelial sodium channel (ENaC) activity
and increase mucus clearance in the airways. ENaC activity is increased in cystic
fibrosis. In addition, nafamostat may inhibit the activity of transmembrane protease,
serine 2 (TMPRSS2), a host cell serine protease that mediates viral cell entry for
influenza virus and coronavirus, thereby inhibiting viral infection and replication.;
UNII : 1D2T74921W;
InChIKey : SRXKIZXIRHMPFW-UHFFFAOYSA-N;
CAS number : 82956-11-4;
Molecule name : FUT 175; FUT-175; CKD-314;
Chemical formula : C19H17N5O2.2CH4O3S;
PubMed : 21187179;
Origin ID : C96293;
UMLS CUI : C0207682;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
