Preferred Label : Nafamostat;
NCIt synonyms : 6-Amidino2-naphthyl 4-guanidinobenzoate; 6-(Aminoiminomethyl)-2-naphthalenyl 4-((aminoiminomethyl)amino)benzoate;
NCIt definition : A broad-spectrum, synthetic serine protease inhibitor, with anticoagulant, anti-inflammatory,
mucus clearing, and potential antiviral activities. Upon administration, nafamostat
inhibits the activities of a variety of proteases, including thrombin, plasmin, kallikrein,
trypsin, and Cl esterase in the complement system, and factors VIIa, Xa, and XIIa
in the coagulation system. Although the mechanism of action of nafamostat is not fully
understood, trypsinogen activation in the pancreas is known to be a trigger reaction
in the development of pancreatitis. Nafamostat blocks the activation of trypsinogen
to trypsin and the inflammatory cascade that follows. Nafamostat may also decrease
epithelial sodium channel (ENaC) activity and increase mucus clearance in the airways.
ENaC activity is increased in cystic fibrosis. In addition, nafamostat may inhibit
the activity of transmembrane protease, serine 2 (TMPRSS2), a host cell serine protease
that mediates viral cell entry for influenza virus and coronavirus, thereby inhibiting
viral infection and replication.;
UNII : Y25LQ0H97D;
InChIKey : MQQNFDZXWVTQEH-UHFFFAOYSA-N;
CAS number : 81525-10-2;
Chemical formula : C19H17N5O2;
PubMed : 18670364;
Origin ID : C96292;
UMLS CUI : C0207683;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_salt_form
- is_free_acid_or_base_form_of
