Preferred Label : Foscenvivint;
NCIt synonyms : CBP/beta-catenin Antagonist PRI-724;
NCIt definition : A potent, specific inhibitor of the canonical Wnt signaling pathway in cancer stem
cells with potential antineoplastic activity. Foscenvivint specifically inhibits the
recruiting of beta-catenin with its coactivator CBP (the binding protein of the cAMP
response element-binding protein CREB); together with other transcription factors
beta-catenin/CBP binds to WRE (Wnt-responsive element) and activates transcription
of a wide range of target genes of Wnt/beta-catenin signaling. Blocking the interaction
of CBP and beta-catenin by this agent prevents gene expression of many proteins necessary
for growth, thereby potentially suppressing cancer cell growth. The Wnt/beta-catenin
signaling pathway regulates cell morphology, motility, and proliferation; aberrant
regulation of this pathway leads to neoplastic proliferation.;
UNII : 43Y934BBZ6;
CAS number : 1422253-38-0;
Molecule name : PRI-724;
NCI Metathesaurus CUI : CL428291;
Origin ID : C95894;
UMLS CUI : C5557439;
Semantic type(s)
- concept_is_in_subset
- has_target
