Preferred Label : STAT3 Inhibitor OPB-51602;
NCIt definition : An orally bioavailable inhibitor of signal transducer and activator of transcription
3 (STAT3), with potential antineoplastic activity. STAT3 inhibitor OPB-51602 inhibits
the phosphorylation and thus the activation of STAT3 protein, impeding STAT3 protein
from translocating from the cytoplasm to the nucleus and thereby blocking STAT3's
regulation of gene expression through direct binding to the promoters of responsive
genes. STAT3 regulates the cellular functions that lead to the cancer phenotype, and
constitutive activation of STAT3 is observed in a wide range of human cancers, inducing
uncontrolled proliferation and neoplastic transformation.;
Molecule name : OPB-51602;
NCI Metathesaurus CUI : CL428286;
Origin ID : C95889;
UMLS CUI : C3272413;
Semantic type(s)
- concept_is_in_subset
- has_target
