" /> Puromycin-Sensitive Aminopeptidase - CISMeF





Preferred Label : Puromycin-Sensitive Aminopeptidase;

NCIt synonyms : AAP-S; EC 3.4.11.14; PSA; Cytosol Alanyl Aminopeptidase; NPEPPS;

NCIt definition : Puromycin-sensitive aminopeptidase (919 aa, 103 kDa) is encoded by the human NPEPPS gene. This protein plays a role in peptide cleavage.;

NCIt note : Puromycin-sensitive aminopeptidase may have hyperphosphorylated tau as a substrate. Enhancement of the activity of the enzyme is a candidate therapy for neuropathies where tau accumulation occurs, such as Alzheimer disease. (Hum. Mol. Genet. 2011; 20: doi: 10.1093/hmg/ddr065.);

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29/07/2025


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