NCIt definition : Puromycin-sensitive aminopeptidase (919 aa, 103 kDa) is encoded by the human NPEPPS
gene. This protein plays a role in peptide cleavage.;
NCIt note : Puromycin-sensitive aminopeptidase may have hyperphosphorylated tau as a substrate.
Enhancement of the activity of the enzyme is a candidate therapy for neuropathies
where tau accumulation occurs, such as Alzheimer disease. (Hum. Mol. Genet. 2011;
20: doi: 10.1093/hmg/ddr065.);