Puromycin-Sensitive Aminopeptidase

Preferred Label : Puromycin-Sensitive Aminopeptidase;

NCIt synonyms : AAP-S; EC 3.4.11.14; PSA; Cytosol Alanyl Aminopeptidase; NPEPPS;

NCIt definition : Puromycin-sensitive aminopeptidase (919 aa, 103 kDa) is encoded by the human NPEPPS gene. This protein plays a role in peptide cleavage.;

NCIt note : Puromycin-sensitive aminopeptidase may have hyperphosphorylated tau as a substrate. Enhancement of the activity of the enzyme is a candidate therapy for neuropathies where tau accumulation occurs, such as Alzheimer disease. (Hum. Mol. Genet. 2011; 20: doi: 10.1093/hmg/ddr065.);

Details

Origin ID

C95861;

UMLS CUI

C1721284;

Automatic exact mappings (from CISMeF team)
- Acute apical periodontitis of pulpal origin [ICD-11 Sub-sub category]
- Aminopeptidase, puromycin-sensitive [OMIM gene]
- Kallikrein-related peptidase 3 [OMIM gene]
- PSA [MedDRA LLT]
- Prostate specific antigen positive [ICD-11 Sub-sub category]
- Prostate-Specific antigen [MeSH Descriptor]
- Prostatic specific antigen [MedDRA Preferred Term]
- Protein s [OMIM gene]
- Salivary gland adenoma, pleomorphic [OMIM Phenotype]
- Serpin peptidase inhibitor, clade f, member 2 [OMIM gene]
- aminopeptidase puromycin sensitive [HGNC gene]
- phosphoserine aminotransferase 1 [ORDO Gene]
- polysialic acid [MeSH Supplementary Concept]
- puromycin-sensitive aminopeptidase [MeSH concept]
- serpin family F member 2 [ORDO Gene]
OMIM relation
- Aminopeptidase, puromycin-sensitive [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- NPEPPS protein, human [MeSH Supplementary Concept]
- NPEPPS protein, human [MeSH concept]
- puromycin-sensitive aminopeptidase [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Metallopeptidase Gene [NCIt concept]
- NPEPPS Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_chemical_classification
- Metalloprotein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Metal Binding Site [NCIt concept]
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_biomarker_type
- Metastasis and Aggressiveness Marker [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Metal Ion Binding [NCIt concept]
- Peptide Metabolism [NCIt concept]
- Proteolysis [NCIt concept]
- Proteolytic Processing [NCIt concept]
is_target
- Tosedostat [NCIt concept]

Keyword's position in hierarchy(ies) :

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