Carboxypeptidase E-deltaN

Preferred Label : Carboxypeptidase E-deltaN;

NCIt synonyms : CPE-deltaN; CPE-delta N; N-Terminally Truncated Carboxypeptidase E;

NCIt definition : Carboxypeptidase E-deltaN (382 aa, 43 kDa) is encoded by the human CPE gene. This protein is involved in the mediation of proteolysis.;

NCIt note : Carboxypeptidase E-deltaN results from alternative splicing of the CPE gene that has an alternative start site in exon 1 and an alternative stop in exon 9. Expression of this protein may be a biomarker for tumor metastasis. (J Clin Invest. doi:10.1172/JCI40433.);

Details

Origin ID

C95810;

UMLS CUI

C3272367;

OMIM relation
- Carboxypeptidase e [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
gene_encodes_gene_product
- CPE Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Metallopeptidase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_abnormality
- Protein Splicing Abnormality [NCIt concept]
- Protein Truncation Abnormality [NCIt concept]
gene_product_has_chemical_classification
- Metalloprotein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_biomarker_type
- Metastasis and Aggressiveness Marker [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Metal Ion Binding [NCIt concept]
- Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients