Tafasitamab - CISMeF

Preferred Label : Tafasitamab;

NCIt synonyms : Immunoglobulin, Anti-(Human Cd19 Antigen) (Human-mus musculus Monoclonal MOR00208 Heavy Chain), Disulfide with Human-mus musculus Monoclonal MOR00208 .Kappa.-chain, Dimer; Tafasitamab-cxix;

NCIt definition : An Fc engineered, humanized anti-CD19 monoclonal antibody directed against the B-cell-specific membrane protein CD19 with potential immunostimulating and antineoplastic activities.Tafasitamab targets and binds to CD19, thereby depleting and eliminating CD19-expressing B-cells. The modified Fc region of XmAb5574 increases binding affinity to Fc-gamma receptors of effector cells and thereby enhances antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cell-mediated phagocytosis (ADCP). CD19 is widely expressed during B-cell development, from pro-B-cell to early plasma cell stages.;

UNII : QQA9MLH692;

CAS number : 1422527-84-1;

Drug name : Monjuvi;

Molecule name : XmAb-5574; MOR-208; MOR-00208; MOR 00208; MOR 208;

NCI Metathesaurus CUI : CL421662;

Codes from synonyms : 318;

Details

Origin ID

C95768;

UMLS CUI

C5139916;

Currated CISMeF NLP mapping
- Tafasitamab [SMS substance]
- Tafasitamab (substance) [SNOMED CT concept]
- tafasitamab [MeSH Supplementary Concept]
- tafasitamab [MeSH concept]
Manual BTNT mappings - CISMeF
- tafasitamab [ATC Code]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing tafasitamab (medicinal product) [SNOMED CT concept]
- Tafasitamab (substance) [SNOMED CT concept]
- tafasitamab [MeSH Supplementary Concept]
- tafasitamab [ATC Code]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- B-Lymphocyte Antigen CD19 [NCIt concept]
is_component_of_chemotherapy_regimen
- Lenalidomide/Tafasitamab Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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