" /> Tafasitamab - CISMeF





Preferred Label : Tafasitamab;

NCIt synonyms : Immunoglobulin, Anti-(Human Cd19 Antigen) (Human-mus musculus Monoclonal MOR00208 Heavy Chain), Disulfide with Human-mus musculus Monoclonal MOR00208 .Kappa.-chain, Dimer; Tafasitamab-cxix;

NCIt definition : An Fc engineered, humanized anti-CD19 monoclonal antibody directed against the B-cell-specific membrane protein CD19 with potential immunostimulating and antineoplastic activities.Tafasitamab targets and binds to CD19, thereby depleting and eliminating CD19-expressing B-cells. The modified Fc region of XmAb5574 increases binding affinity to Fc-gamma receptors of effector cells and thereby enhances antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cell-mediated phagocytosis (ADCP). CD19 is widely expressed during B-cell development, from pro-B-cell to early plasma cell stages.;

UNII : QQA9MLH692;

CAS number : 1422527-84-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1422527-84-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Monjuvi;

Molecule name : XmAb5574; MOR208; MOR-00208;

NCI Metathesaurus CUI : CL421662;

Codes from synonyms : 318;

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15/05/2024


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