NCIt definition : A second-generation antisense oligonucleotide targeting the eukaryotic translation
initiation factor 4E (eIF4E) with potential antitumor activity. Antisense oligonucleotide
ISIS EIF4ERx suppresses the expression of eIF4E in fast dividing tumor cells. Blocking
the expression of eIF4E results in inhibition of the synthesis of tumor angiogenic
factors, thereby leading to the inhibition of cellular proliferation and apoptosis
in tumor cells. eIF4E is overexpressed in a variety of cancers, is involved in the
mRNA-ribosome binding step of eukaryotic protein synthesis and is the rate-limiting
component of the eukaryotic translation apparatus.;