MEK Inhibitor GDC-0623

Preferred Label : MEK Inhibitor GDC-0623;

NCIt related terms : GDC-0623;

NCIt definition : An orally active, selective MEK inhibitor with potential antineoplastic activity. MEK inhibitor GDC-0623 specifically inhibits mitogen-activated protein kinase kinase (MEK or MAP/ERK kinase), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth; constitutive activation of this pathway has been implicated in many cancers.;

UNII : HW67545I4Q;

CAS number : 1168091-68-6;

Molecule name : GDC-0623;

NCI Metathesaurus CUI : CL421583;

Details

Origin ID

C95738;

UMLS CUI

C2987389;

Currated CISMeF NLP mapping
- GDC-0623 [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- GDC-0623 [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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