NCIt definition : An orally active, selective MEK inhibitor with potential antineoplastic activity.
MEK inhibitor GDC-0623 specifically inhibits mitogen-activated protein kinase kinase
(MEK or MAP/ERK kinase), resulting in inhibition of growth factor-mediated cell signaling
and tumor cell proliferation. MEK is a key component of the RAS/RAF/MEK/ERK signaling
pathway that regulates cell growth; constitutive activation of this pathway has been
implicated in many cancers.;
UNII : HW67545I4Q;
CAS number : 1168091-68-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1168091-68-6
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;