PI3K Inhibitor ZSTK474

Preferred Label : PI3K Inhibitor ZSTK474;

NCIt synonyms : Phosphatidylinositol 3-kinase Inhibitor ZSTK474;

NCIt related terms : ZSTK-474;

NCIt definition : An orally available, s-triazine derivative, ATP-competitive phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor ZSTK474 inhibits all four PI3K isoforms. Inhibiting the activation of the PI3K/AKT kinase (or protein kinase B) signaling pathway results in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents. This agent does not induce apoptosis but rather induces strong G(0)/G(1) arrest, which might contribute to its favorable efficacy in tumor cells.;

UNII : K0068GK39A;

InChIKey : HGVNLRPZOWWDKD-UHFFFAOYSA-N;

CAS number : 475110-96-4;

Molecule name : ZSTK474;

Details

Origin ID

C95723;

UMLS CUI

C1721602;

Currated CISMeF NLP mapping
- ZSTK474 [MeSH concept]
- ZSTK474 [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ZSTK474 [MeSH Supplementary Concept]
- ZSTK474 [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Phosphatidylinositol-4,5-Bisphosphate 3-Kinase [NCIt concept]

Keyword's position in hierarchy(ies) :

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