Preferred Label : MUC1-targeted Peptide GO-203-2C;
NCIt related terms : GO-203-2C;
NCIt definition : An optimized small peptide drug candidate targeting epithelial mucin (MUC1) with antineoplastic
activity. MUC1-targeted peptide GO-203-2C interacts with oncoprotein MUC1 C-terminal
subunit on the cell surface, thereby impeding cell-cell interactions, signaling, and
metastasis. MUC1 antigen, a membrane bound glycoprotein expressed by most glandular
and ductal epithelial cells, is over-expressed in many diverse human carcinomas including
those of the breast, prostate, lung, colon, pancreas, and ovary, and has been associated
with poor prognosis.;
UNII : 5YSY733NA3;
InChIKey : MDQMFOHHSFMREL-YIYMUJAPSA-N;
CAS number : 1469735-88-3;
Molecule name : GO-203-2C;
NCI Metathesaurus CUI : CL428184;
Origin ID : C95722;
UMLS CUI : C2987373;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
