Preferred Label : Iodine I 124-labeled Hsp90 Inhibitor PUH71;
NCIt synonyms : Iodine I 124 PUH71; 124I-PUH71;
NCIt definition : A radioconjugate containing the purine scaffold heat shock protein 90 (Hsp90) inhibitor
PUH71 labeled with the radioisotope iodine I 124, with positron emitting activity.
Hsp90 inhibitor PUH71 is thought to bind to cytosolic Hsp90 and the endoplasmic reticulum
paralogue gp96 (HSP90B1), thereby inhibiting its molecular chaperone function and
promoting the degradation of the oncogenic signaling proteins. This induces caspase-dependent
apoptosis. The iodine I 124 moiety can be visualized using Positron emission tomography
(PET) imaging, thereby allowing an assessment of the accumulation of PUH71 in vivo,
particularly in tumors. Hsp90, a chaperone protein upregulated in a variety of tumor
cells, regulates the folding, stability and degradation of many oncogenic signaling
proteins.;
PubMed : 20977755;
Origin ID : C95711;
UMLS CUI : C2987351;
Semantic type(s)
- concept_is_in_subset
- has_target
