" /> Bermekimab - CISMeF





Preferred Label : Bermekimab;

NCIt synonyms : Anti-IL-1 alpha Monoclonal Antibody MABp1;

NCIt definition : A human immunoglobulin (Ig) G1 monoclonal antibody directed against interleukin-1 alpha (IL-1a) and derived from human B-lymphocytes that were obtained from a natural human immune response against IL-1a, with potential antineoplastic, anti-inflammatory, anti-cachectic and anti-angiogenic activities. Upon administration, bermekimab targets, binds to and neutralizes IL-1a thereby preventing IL-1a activity. This prevents IL-1a-mediated inflammation, tumorigenesis and angiogenesis. In addition, bermekimab may abrogate IL-1a-mediated cachexia and stimulate metabolic activity in the central nervous system (CNS). IL-1a, an inflammatory mediator expressed on monocytes, platelets and overexpressed by certain tumors, plays a key role in the promotion of tumor cell growth, metastasis and invasion.;

UNII : N6SVN735GY;

CAS number : 1401965-15-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1401965-15-8 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Xilonix;

Molecule name : CA-18C3; RA-18C3; CV-18C3; CV 18C3; RA 18C3; JNJ-77474462; MABp1;

NCI Metathesaurus CUI : CL428173;

Details


You can consult :


Nous contacter.
15/05/2024


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.