Preferred Label : Bermekimab;
NCIt synonyms : Anti-IL-1 alpha Monoclonal Antibody MABp1;
NCIt definition : A human immunoglobulin (Ig) G1 monoclonal antibody directed against interleukin-1
alpha (IL-1a) and derived from human B-lymphocytes that were obtained from a natural
human immune response against IL-1a, with potential antineoplastic, anti-inflammatory,
anti-cachectic and anti-angiogenic activities. Upon administration, bermekimab targets,
binds to and neutralizes IL-1a thereby preventing IL-1a activity. This prevents IL-1a-mediated
inflammation, tumorigenesis and angiogenesis. In addition, bermekimab may abrogate
IL-1a-mediated cachexia and stimulate metabolic activity in the central nervous system
(CNS). IL-1a, an inflammatory mediator expressed on monocytes, platelets and overexpressed
by certain tumors, plays a key role in the promotion of tumor cell growth, metastasis
and invasion.;
UNII : N6SVN735GY;
CAS number : 1401965-15-8;
Drug name : Xilonix;
Molecule name : CA-18C3; RA-18C3; CV-18C3; CV 18C3; RA 18C3; JNJ-77474462; MABp1;
NCI Metathesaurus CUI : CL428173;
Origin ID : C95708;
UMLS CUI : C4542166;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
