Pirarubicin Hydrochloride

Preferred Label : Pirarubicin Hydrochloride;

NCIt synonyms : THP-adriamycin Hydrochloride; (2R)-4'-O-Tetrahydropyranyladriamycin Hydrochloride; 4'-O-Tetrahydropyranyl Doxorubicin HCl;

NCIt related terms : THP-ADM;

NCIt definition : The hydrochloride salt form of pirarubicin, an analogue of the anthracycline antineoplastic antibiotic doxorubicin with antineoplastic activity. Pirarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair as well as RNA and protein synthesis. This agent is less cardiotoxic than doxorubicin and exhibits activity against some doxorubicin-resistant cell lines.;

UNII : E7V83174BE;

InChIKey : ZPHYPKKFSHAVOE-YZIXBPQXSA-N;

CAS number : 72496-41-4;

Chemical formula : C32H37NO12.ClH;

NSC code : 333054;

Codes from synonyms : NSC0333054;

Details

Origin ID

C95319;

UMLS CUI

C0898957;

Currated CISMeF NLP mapping
- pirarubicin hydrochloride [MeSH concept]
Manual NTBT mappings (CISMeF)
- Pirarubicin (substance) [SNOMED CT concept]
Semantic type(s)
- Antibiotic [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- pirarubicin hydrochloride [MeSH concept]
Validated automatic mappings to NTBT
- pirarubicin [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Pirarubicin [NCIt concept]
is_salt_form_of
- Pirarubicin [NCIt concept]

Keyword's position in hierarchy(ies) :

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