Preferred Label : Pirarubicin;
NCIt synonyms : THP-Adriamycin; [8S-[8Alpha,10alpha(S*)]]-10-[[3-amino-2,3,6-trideoxy-4-O-(tetrahydro-2H-pyran-2-yl)-alpha-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione; (2R)-4'-O-Tetrahydropyranyladriamycin; (8S,10S)-10-[[3-Amino-2,3,6-trideoxy-4-O-(tetrahydro-2H-pyran-3-yl)-alpha-L-lyxo-hexopyranosyl]oxy]-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione; 4'-O-Tetrahydropyranyl Doxorubicin; THP-DOX; THP-Doxorubicin; Tepirubicin; Tetrahydropyranyl-Doxorubicin;
NCIt related terms : THP-ADM;
NCIt definition : An analogue of the anthracycline antineoplastic antibiotic doxorubicin. Pirarubicin
intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA
replication and repair and RNA and protein synthesis. This agent is less cardiotoxic
than doxorubicin and exhibits activity against some doxorubicin-resistant cell lines.
(NCI04);
UNII : D58G680W0G;
InChIKey : KMSKQZKKOZQFFG-YXRRJAAWSA-N;
CAS number : 72496-41-4;
Drug name : Theprubicine; Theprubicin; Pinorubicin; Therarubicin;
Molecule name : 1609-RB;
Chemical formula : C32H37NO12;
Codes from synonyms : NSC0333054; 405;
Origin ID : C1197;
UMLS CUI : C0071126;
CISMeF manual mappings
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_salt_form
- is_component_of_chemotherapy_regimen
- is_free_acid_or_base_form_of
