KLLN wt Allele

Preferred Label : KLLN wt Allele;

NCIt synonyms : Killin Protein Gene; KLN; CWS4; KILLIN; Killin, p53-Regulated DNA Replication Inhibitor Gene; Killin, p53 Regulated DNA Replication Inhibitor wt Allele;

NCIt definition : Human KLLN wild-type allele is located in the vicinity of 10q23 and is approximately 4 kb in length. This allele, which encodes killin protein, plays a role in both DNA binding and the mediation of p53-mediated apoptosis.;

NCIt note : Methylation of the KILLIN gene promoter may be associated with Cowden syndrome, Cowden-like syndrome and cancer susceptibility. (JAMA. 2010; 304:2724-2731.); The human KILLIN gene shares promoter sequences with the human PTEN gene. (OMIM);

GenBank Accession Number : EU552092;

Details

Origin ID

C95287;

UMLS CUI

C3272349;

Automatic exact mappings (from CISMeF team)
- Killin [OMIM gene]
- killin, p53 regulated DNA replication inhibitor [ORDO Gene]
OMIM relation
- Killin [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_plays_role_in_process
- Apoptosis [NCIt concept]
- Cell Cycle Regulation Process [NCIt concept]
- DNA Binding [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients