NCIt synonyms : Killin Protein Gene; KLN; Killin, p53-Regulated DNA Replication Inhibitor wt Allele; KILLIN;
NCIt definition : Human KILLIN wild-type allele is located in the vicinity of 10q23 and is approximately
4 kb in length. This allele, which encodes killin protein, plays a role in both DNA
binding and the mediation of p53-mediated apoptosis.;
NCIt note : Methylation of the KILLIN gene promoter may be associated with Cowden syndrome, Cowden-like
syndrome and cancer susceptibility. (JAMA. 2010; 304:2724-2731.); The human KILLIN gene shares promoter sequences with the human PTEN gene. (OMIM);