" /> Lutetium Lu 177 Dotatate - CISMeF





Preferred Label : Lutetium Lu 177 Dotatate;

NCIt synonyms : Lutetium Lu 177 DOTA(0)-Tyr(3)-Octreotate; 177Lu-DOTA0-Tyr3-Octreotate; Lutetium Lu 177-DOTA-Tyr3-Octreotate; lutetium Lu 177-DOTATATE; 177 Lu-DOTA-Tyr3-Octreotate; 177 Lu-DOTA-TATE;

NCIt related terms : LUTETIUM OXODOTREOTIDE LU-177;

NCIt definition : A radioconjugate consisting of the tyrosine-containing somatostatin analog Tyr3-octreotate (TATE) conjugated with the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA) and radiolabeled with the beta-emitting radioisotope lutetium Lu 177, with potential imaging and antineoplastic activities. Lutetium Lu 177 dotatate binds to somatostatin receptors (SSTRs), with high affinity to type 2 SSTR, present on the cell membranes of many types of neuroendocrine tumor (NET) cells. Upon binding and internalization, this radioconjugate specifically delivers a cytotoxic dose of beta radiation to SSTR-positive cells. Tyr3-octreotate (TATE) is an octreotide derivative in which phenylalanine at position 3 is substituted by tyrosine and position 8 threoninol is replaced with threonine. SSTRs have been shown to be present in large numbers on NET and their metastases, while most other normal tissues express low levels of SSTRs.;

UNII : AE221IM3BB;

InChIKey : MXDPZUIOZWKRAA-PRDSJKGBSA-K;

CAS number : 437608-50-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 437608-50-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Lutathera;

NCI Metathesaurus CUI : CL433757;

Codes from synonyms : 316;

PubMed : 20168290; 18649310;

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15/05/2024


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