Preferred Label : BRAF Inhibitor ARQ 736;
NCIt related terms : ARQ-736;
NCIt definition : An orally bioavailable, highly soluble phosphate prodrug of B-raf (BRAF) protein kinase
with potential antineoplastic activity. BRAF inhibitor ARQ 736 is converted into its
active form ARQ 680 in the presence of phosphatases. In turn, ARQ 680 selectively
binds to and inhibits the activity of oncogenic B-raf, which may inhibit the proliferation
of tumor cells expressing mutated B-raf gene. B-raf belongs to the raf/mil family
of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs
signaling pathway, which may be constitutively activated due to BRAF gene mutations.
The valine to glutamic acid substitution at residue 600 (V600E) accounts for about
90% of BRAF gene mutations.;
UNII : Y2H4S74Y8U;
InChIKey : HXINDCTZKGGRDE-JPKZNVRTSA-L;
CAS number : 1228237-57-7;
Molecule name : AQ 736;
NCI Metathesaurus CUI : CL433988;
Origin ID : C94224;
UMLS CUI : C2986409;
Semantic type(s)
- concept_is_in_subset
- has_target
