Alpelisib - CISMeF

Preferred Label : Alpelisib;

NCIt synonyms : Phosphoinositide 3-kinase Inhibitor BYL719;

NCIt definition : An orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Alpelisib specifically inhibits PI3K in the PI3K/AKT kinase (or protein kinase B) signaling pathway, thereby inhibiting the activation of the PI3K signaling pathway. This may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents.;

UNII : 08W5N2C97Q;

InChIKey : STUWGJZDJHPWGZ-LBPRGKRZSA-N;

CAS number : 1217486-61-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1217486-61-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Piqray; VIJOICE;

Molecule name : BYL719;

Codes from synonyms : 10396;

Details

Origin ID

C94214;

UMLS CUI

C4055478;

Automatic exact mappings (from CISMeF team)
- Alpelisib [ICD-11 Extension code]
Currated CISMeF NLP mapping
- Alpelisib [MeSH concept]
- Alpelisib [MeSH Supplementary Concept]
- Alpelisib (substance) [SNOMED CT concept]
See also inter- (CISMeF)
- Piqray [MeSH concept]
- Product containing alpelisib (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Alpelisib [MeSH Supplementary Concept]
- Alpelisib (substance) [SNOMED CT concept]
- Product containing alpelisib (medicinal product) [SNOMED CT concept]
- alpelisib [ATC Code]
Validated automatic mappings to BTNT
- alpelisib [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Phosphatidylinositol-4,5-Bisphosphate 3-Kinase [NCIt concept]
is_component_of_chemotherapy_regimen
- Alpelisib/Fulvestrant Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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