NCIt definition : An orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential
antineoplastic activity. Alpelisib specifically inhibits PI3K in the PI3K/AKT kinase
(or protein kinase B) signaling pathway, thereby inhibiting the activation of the
PI3K signaling pathway. This may result in inhibition of tumor cell growth and survival
in susceptible tumor cell populations. Activation of the PI3K signaling pathway is
frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute
to tumor resistance to a variety of antineoplastic agents.;