NCIt definition : A fusion protein containing a modified form of human T-cell receptor (TCR) specific
for the gp100 antigen and fused to an anti-CD3 single-chain antibody fragment, with
potential antineoplastic activity. Upon direct intratumoral administration of tebentafusp
into the melanoma lesion, the TCR moiety of this agent targets and binds to the tumor
associated antigen (TAA) gp100 presented on the melanoma tumor cell; the anti-CD3
fragment moiety binds to CD3- expressing T lymphocytes, thereby selectively cross-linking
tumor cells and T-lymphocytes. This may lead to the recruitment of cytotoxic T lymphocytes
(CTL) to the T lymphocyte/tumor cell aggregates and result in CTL-mediated death of
gp100-expressing melanoma cancer cells.;