NCIt synonyms : Adenocarcinoma of the Esophagogastric Junction; Adenocarcinoma of Gastroesophageal Junction; Adenocarcinoma of the EG Junction; Adenocarcinoma of Cardioesophageal Junction; Adenocarcinoma of the GE Junction; Adenocarcinoma of the Cardioesophageal Junction;
NCIt related terms : Adenocarcinoma - GEJ; Adenocarcinoma of the gastroesophageal junction;
NCIt definition : An adenocarcinoma that arises from and straddles the junction of the stomach and esophagus.
The category of adenocarcinomas of the gastroesophageal junction also includes the
majority of adenocarcinomas previously called gastric cardia adenocarcinomas. Squamous
cell carcinomas that affect or cross the junction of the stomach and esophagus are
classified as carcinomas of the distal esophagus. Adenocarcinoma of the gastroesophageal
junction occurs more often in Caucasian middle aged and elderly males. Clinical signs
and symptoms include dysphagia, abdominal pain, and weight loss. The prognosis depends
on the completeness of the surgical resection, the number of lymph nodes involved
by cancer, and the presence or absence of postoperative complications. The presence
of TP53 mutations indicates worse prognosis.;