Preferred Label : Epacadostat;
NCIt synonyms : 1,2,5-Oxadiazole-3-carboximidamide, 4-((2-((Aminosulfonyl)amino)ethyl)amino)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-,
(C(Z))-;
NCIt definition : An orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase (IDO1),
with potential immunomodulating and antineoplastic activities. Epacadostat targets
and binds to IDO1, an enzyme responsible for the oxidation of tryptophan into kynurenine.
By inhibiting IDO1 and decreasing kynurenine in tumor cells, INCB024360 increases
and restores the proliferation and activation of various immune cells, including dendritic
cells (DCs), NK cells, and T-lymphocytes, as well as interferon (IFN) production,
and a reduction in tumor-associated regulatory T cells (Tregs). Activation of the
immune system, which is suppressed in many cancers, may inhibit the growth of IDO1-expressing
tumor cells. IDO1 is overexpressed by a variety of tumor cell types and DCs.;
UNII : 71596A9R13;
InChIKey : FBKMWOJEPMPVTQ-UHFFFAOYSA-N;
CAS number : 1204669-58-8;
Molecule name : INCB024360; INCB 024360;
NCI Metathesaurus CUI : CL423831;
Origin ID : C92582;
UMLS CUI : C4086265;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_target
