Merkel Cell Carcinoma

Preferred Label : Merkel Cell Carcinoma;

NCIt synonyms : Neuroendocrine Carcinoma of the Skin; MCC;

NCIt related terms : Merkel cell tumor; Merkel cell cancer; Merkel cell carcinoma, unspecified;

NCIt definition : A rare aggressive neuroendocrine carcinoma that usually arises from the skin. Rarely, it arises from extracutaneous sites, including the oral cavity, salivary glands, breast, vulva, and vaginal wall. The tumor is composed of small round cells with scanty cytoplasm. Merkel cell polyomavirus is implicated in the majority of cases.;

Neoplastic status : Malignant;

ICD-O code : 8247/3;

Codes from synonyms : CDR0000658511; 10029266; CDR0000046106; C4A.9;

Details

Origin ID

C9231;

UMLS CUI

C0007129;

Automatic exact mappings (from CISMeF team)
- Mcc regulator of wnt signaling pathway [OMIM gene]
- Merkel cell carcinoma of skin [ICD-11 More detail]
- Merkel cell skin cancer [HPO term]
- genes, MCC [MeSH concept]
- mitotic checkpoint complex [GO term]
- mucociliary clearance [GO term]
- skin cancer [MedlinePlus Topic]
CISMeF manual mappings
- Apudoma of skin (disorder) [SNOMED CT concept]
Currated CISMeF NLP mapping
- Cutaneous neuroendocrine carcinoma [ICD-11 Category]
- Cutaneous neuroendocrine carcinoma [ORDO Disease]
- Merkel cell carcinoma [PASCAL descriptor]
- Merkel cell carcinoma [DO Concept]
- Merkel cell carcinoma [Disease (Nov.)]
- Merkel cell carcinoma [ICD-11 Extension code]
- Merkel cell carcinoma [ICD-O code]
- Merkel cell carcinoma [MedDRA LLT]
- Merkel cell carcinoma (disorder) [SNOMED CT concept]
- Merkel cell carcinoma (morphologic abnormality) [SNOMED CT concept]
- Neuroendocrine carcinoma of the skin [MedDRA Preferred Term]
- carcinoma, merkel cell [MeSH Descriptor]
- carcinoma, merkel cell [MeSH concept]
- merkel cell carcinoma [SNOMED Notion]
Disease excludes abnormal cell
- Large Osteoclastic Giant Cell [NCIt concept]
- Malignant Stromal Cell [NCIt concept]
- Neoplastic Endothelial Cell [NCIt concept]
- Neoplastic Smooth Muscle Cell [NCIt concept]
Disease excludes normal cell origin
- Endothelial Cell [NCIt concept]
Disease may have findings
- Diffuse Pattern [NCIt concept]
- Nodular Pattern [NCIt concept]
- Trabecular Pattern [NCIt concept]
Excludes anatomical site(s)
- Head and Neck [NCIt concept]
- Lung [NCIt concept]
Has associated anatomic sites
- Integumentary System [NCIt concept]
- Skin [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Apudoma of skin (disorder) [SNOMED CT concept]
- Cutaneous neuroendocrine carcinoma [ORDO Disease]
- Merkel cell carcinoma [PASCAL descriptor]
- Merkel cell carcinoma [ICD-O code]
- Merkel cell carcinoma [Disease (Nov.)]
- Merkel cell carcinoma [MedDRA LLT]
- Merkel cell carcinoma (disorder) [SNOMED CT concept]
- Merkel cell carcinoma (morphologic abnormality) [SNOMED CT concept]
- Merkel cell skin cancer [HPO term]
- Neuroendocrine carcinoma of the skin [MedDRA Preferred Term]
- carcinoma, merkel cell [MeSH concept]
- carcinoma, merkel cell [MeSH Descriptor]
- merkel cell carcinoma [SNOMED Notion]
concept_is_in_subset
- CPTAC Codelists Terminology [NCIt concept]
- CPTAC Neoplasms Codelist [NCIt concept]
- CPTAC Terminology [NCIt concept]
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Cellosaurus Disease Terminology [NCIt concept]
- Cellosaurus Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology Terminology [NCIt concept]
- Mapped ICDO3.1 Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology Terminology [NCIt concept]
- Mapped ICDO3.2 Terminology [NCIt concept]
- NCI CTEP SDC Merkel Cell Tumor Sub-Category Terminology [NCIt concept]
- NCI CTEP Simplified Disease Classification Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
- mCode Cancer Disorder Value Set [NCIt concept]
- mCode Elixhauser Malignant Solid Tumors without Metastases Value Set [NCIt concept]
- mCode Primary Cancer Disorder Value Set [NCIt concept]
- mCode Primary Malignant Neoplasm Disorder Value Set [NCIt concept]
- mCode Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Favorable Clinical Outcome [NCIt concept]
- Intermediate Grade Neuroendocrine Lesion [NCIt concept]
- Well Differentiated Neuroendocrine Lesion [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Malignant Endocrine Cell [NCIt concept]
- Malignant Epithelial Cell [NCIt concept]
- Malignant Neuroendocrine Cell [NCIt concept]
- Malignant Neuroendocrine Small Round Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Endocrine Cell [NCIt concept]
- Neoplastic Epithelial Cell [NCIt concept]
- Neoplastic Neuroendocrine Cell [NCIt concept]
disease_has_finding
- Carcinomatous Component Present [NCIt concept]
- Cutaneous Involvement [NCIt concept]
- Cytoplasmic Membrane-Bound Granules Present [NCIt concept]
- Endocrine Differentiation [NCIt concept]
- Epithelial Component Present [NCIt concept]
- Expression of Neuroendocrine Markers Present [NCIt concept]
- High Mitotic Activity [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Neuroendocrine Differentiation [NCIt concept]
- Poorly Differentiated Neuroendocrine Lesion [NCIt concept]
- Single Cell Necrosis [NCIt concept]
- Trabecular Pattern [NCIt concept]
disease_has_normal_cell_origin
- Epithelial Cell [NCIt concept]
disease_has_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Dermis [NCIt concept]
- Skin [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Trisomy 6 [NCIt concept]
- del(1p36) [NCIt concept]

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