Pappalysin-1 - CISMeF

Preferred Label : Pappalysin-1;

NCIt synonyms : EC 3.4.24.79; PAPP-A; IGFBP-4ase; Pregnancy-Associated Plasma Protein A; Insulin-Like Growth Factor-Dependent IGF-Binding Protein 4 Protease; IGF-Dependent IGFBP-4 Protease; PAPPA;

NCIt definition : Pappalysin-1 (1627 aa, 181 kDa) is encoded by the human PAPPA gene. This protein is involved in the modulation of proteolysis.;

NCIt note : Pappalysin-1 specifically cleaves IGFBP-4 between 143-Ser and Lys-144 and IGFBP-5 between 135-Met and Lys-136. (UniProt); Low plasma levels of pappalysin-1 during pregnancy may be a biomarker of an aneuploid fetus.;

Details

Origin ID

C91825;

UMLS CUI

C2984583;

Currated CISMeF NLP mapping
- Pregnancy associated plasma protein A [LOINC component]
- Pregnancy associated plasma protein A (substance) [SNOMED CT concept]
- Pregnancy-Associated plasma Protein-A [MeSH concept]
- pregnancy-associated plasma protein-a [MeSH Descriptor]
OMIM relation
- Pappalysin 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Metallopeptidase Gene [NCIt concept]
- PAPPA Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Placenta [NCIt concept]
gene_product_has_biochemical_function
- Peptidase [NCIt concept]
gene_product_has_chemical_classification
- Metalloprotein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Sushi Domain [NCIt concept]
gene_product_is_biomarker_type
- Metastasis and Aggressiveness Marker [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Metal Ion Binding [NCIt concept]
- Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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