" /> Pappalysin-1 - CISMeF





Preferred Label : Pappalysin-1;

NCIt synonyms : EC 3.4.24.79; PAPP-A; IGFBP-4ase; Pregnancy-Associated Plasma Protein A; Insulin-Like Growth Factor-Dependent IGF-Binding Protein 4 Protease; IGF-Dependent IGFBP-4 Protease; PAPPA;

NCIt definition : Pappalysin-1 (1627 aa, 181 kDa) is encoded by the human PAPPA gene. This protein is involved in the modulation of proteolysis.;

NCIt note : Pappalysin-1 specifically cleaves IGFBP-4 between 143-Ser and Lys-144 and IGFBP-5 between 135-Met and Lys-136. (UniProt); Low plasma levels of pappalysin-1 during pregnancy may be a biomarker of an aneuploid fetus.;

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31/07/2025


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