NCIt related terms : U-8344; U 8344; 5-[Bis(2-chloroethyl)amino]uracil;
NCIt definition : An alkylating derivative of the pyrimidine nucleobase uracil that is bound to nitrogen
mustard, with antineoplastic activity. Uramustine alkylates and damages DNA by binding
to the guanine and cytosine moieties of DNA. This leads to cross-linking of DNA, which
inhibits DNA synthesis and promotes cell death in rapidly metabolizing cells, such
as cancer cells.;