Uracil Mustard

Preferred Label : Uracil Mustard;

NCIt synonyms : 5-(bis-(2-Chloroethyl) Amino) Uracil; Uramustine;

NCIt related terms : U-8344; U 8344; 5-[Bis(2-chloroethyl)amino]uracil;

NCIt definition : An alkylating derivative of the pyrimidine nucleobase uracil that is bound to nitrogen mustard, with antineoplastic activity. Uramustine alkylates and damages DNA by binding to the guanine and cytosine moieties of DNA. This leads to cross-linking of DNA, which inhibits DNA synthesis and promotes cell death in rapidly metabolizing cells, such as cancer cells.;

UNII : W7KQ46GJ8U;

InChIKey : IDPUKCWIGUEADI-UHFFFAOYSA-N;

CAS number : 66-75-1;

Molecule name : U-8344;

Chemical formula : C8H11Cl2N3O2;

NSC code : 34462;

ChEBI ID : CHEBI:9884;

Codes from synonyms : NSC0034462; 522;

Details

Origin ID

C918;

UMLS CUI

C0041920;

Automatic exact mappings (from CISMeF team)
- Uracil mustard [ICHI extension code]
- Uramustine [ICHI extension code]
- Uramustine [SMS substance]
- uramustine [ATC Code]
Currated CISMeF NLP mapping
- Uracil mustard [ICD-11 Extension code]
- Uramustine [ICD-11 Extension code]
- Uramustine (substance) [SNOMED CT concept]
- uracil mustard [Substance BNPC]
- uracil mustard [MeSH Descriptor]
- uracil mustard [MeSH concept]
- uracil mustard [SNOMED Notion]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Uracil mustard [ICD-11 Extension code]
- Uramustine [ICD-11 Extension code]
- Uramustine (substance) [SNOMED CT concept]
- uracil mustard [Substance BNPC]
- uracil mustard [MeSH concept]
- uracil mustard [MeSH Descriptor]
- uracil mustard [SNOMED Notion]
- uramustine [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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