Preferred Label : Vesencumab;
NCIt synonyms : Immunoglobulin GL, Anti-(Human Neuropilin 1) (Human Monoclonal MNRP1685a Heavy Chain),
Disulfide with Human Monoclonal MNRP1685a Light Chain, Dimer;
NCIt definition : A human IgG1 monoclonal antibody directed against neuropilin-1 (NRP1), with potential
antiangiogenic and antineoplastic activities. Upon intravenous administration, vesencumab
specifically targets and binds to NRP1; the antibody-NRP1 complex prevents the subsequent
coupling of NRP1 to VEGFR2, thereby potentially inhibiting VEGF-mediated signaling
and potentially preventing angiogenesis. In combination with other anti-VEGF therapies,
vesencumab may enhance their anti-angiogenic effect. NRP1 is a membrane-bound co-receptor
normally expressed by endothelial cells and overexpressed by certain tumor cells,
and plays a role in angiogenesis, cell survival, migration, and invasion.;
UNII : 7SF22186WT;
CAS number : 1205533-60-3;
Molecule name : MNRP-1685A;
Origin ID : C91728;
UMLS CUI : C5139919;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
