Preferred Label : MDM2 Antagonist RO5045337;
NCIt related terms : RO-5045337;
NCIt definition : An MDM2 (human homolog of double minutes-2; HDM2) antagonist with potential antineoplastic
activity. RO5045337 binds to MDM2, thereby preventing the binding of the MDM2 protein
to the transcriptional activation domain of the tumor suppressor protein p53. By preventing
this MDM2-p53 interaction, the proteasome-mediated enzymatic degradation of p53 is
inhibited and the transcriptional activity of p53 is restored, which may result in
the restoration of p53 signaling and thus the p53-mediated induction of tumor cell
apoptosis. MDM2, a zinc finger protein, is a negative regulator of the p53 pathway;
often overexpressed in cancer cells, it has been implicated in cancer cell proliferation
and survival.;
UNII : Q8MI0X869M;
InChIKey : QBGKPEROWUKSBK-QPPIDDCLSA-N;
CAS number : 939981-39-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 939981-39-2
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : R7112; RO-5045337;
NCI Metathesaurus CUI : CL421615;
Origin ID : C91724;
UMLS CUI : C2984515;
Semantic type(s)
- concept_is_in_subset
- has_target
