Zanolimumab - CISMeF

Preferred Label : Zanolimumab;

NCIt synonyms : Anti-CD4 Monoclonal Antibody HuMax; HuMax-CD4;

NCIt definition : A human IgG1k monoclonal antibody against the CD4 receptor on T-lymphocytes, with potential antineoplastic and immunosuppressing activities. Zanolimumab targets and binds to the CD4 receptor on certain T-cells thereby preventing the interaction between the CD4 receptor and the major histocompatibility complex class II molecule. This prevents activation of CD4 positive T cells. In addition, zanolimumab is able to induce an antibody-dependent cellular cytotoxicity (ADCC) response against CD4-expressing tumor cells. CD4, a receptor located on a subset of T-lymphocytes, is upregulated in T-cell lymphomas.;

UNII : HG3L8885M0;

CAS number : 652153-01-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 652153-01-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Details

Origin ID

C91701;

UMLS CUI

C1957794;

Automatic exact mappings (from CISMeF team)
- humax-CD4 [MeSH concept]
Currated CISMeF NLP mapping
- Product containing zanolimumab (medicinal product) [SNOMED CT concept]
- Zanolimumab (substance) [SNOMED CT concept]
- zanolimumab [MeSH concept]
- zanolimumab [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing zanolimumab (medicinal product) [SNOMED CT concept]
- Zanolimumab (substance) [SNOMED CT concept]
- zanolimumab [MeSH Supplementary Concept]
- zanolimumab [MeSH concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- T-Cell Surface Glycoprotein CD4 [NCIt concept]

Keyword's position in hierarchy(ies) :

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