Preferred Label : Mitoguazone Dihydrochloride;
NCIt synonyms : 2,2'-(1-Methyl-1,2-Ethanediylidene)Bis(Hydrazinecarboximidamide) Dihydrochloride; Pyruvaldehyde Bis(amidinohydrazone) Hydrochloride; 1,1'-((Methylethanediylidene)Dinitrilo)Diguanidine Dihydrochloride; Methylglyoxal Bis(amidinohydrazone) Dihydrochloride; MGBG 2HCl;
NCIt definition : The hydrochloride salt of a guanylhydrazone with potential antineoplastic activity.
Mitoguazone competitively inhibits S-adenosyl-L-methionine decarboxylase (SAMD), an
enzyme involved in the synthesis of polyamines, resulting in decreased proliferation
of tumor cells, antimitochondrial effects, and p53-independent apoptosis. Polyamines,
specifically spermine and spermidine, are essential for thymidine kinase production,
DNA synthesis, and cell proliferation.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of some leukemias and lymphomas.
It blocks the growth of cells and may cause cancer cells to die. It is a type of polyamine
synthesis inhibitor.;
UNII : NNI098FX5Q;
InChIKey : VVTBQCXLZQYGQE-PVTAQEPXSA-N;
CAS number : 7059-23-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 7059-23-6
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G-SRS /a ;
Chemical formula : C5H12N8.2HCl;
NSC code : 32946;
Codes from synonyms : CDR0000658021;
Origin ID : C91409;
UMLS CUI : C0771772;
Semantic type(s)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
