Preferred Label : Mitoguazone;
NCIt synonyms : Me-GAG; Methylglyoxal Bisguanylhydrazone; Methyl GAG; methylglyoxal bis(guanylhydrazone); pyruvaldehyde bis(amidinohydrazone); Methyl-G; MGBG; 2,2-(methyl-1,2-ethanediylidene)bis[hydrazinecarboximidamide]; 1,1'-((methylethanediylidene)dinitrilo)diguanidine; Methylglyoxal bis(amidinohydrazone);
NCIt definition : A guanylhydrazone with potential antineoplastic activity. Mitoguazone competitively
inhibits S-adenosyl-L-methionine decarboxylase (SAMD), an enzyme involved in the synthesis
of polyamines, resulting in decreased proliferation of tumor cells, antimitochondrial
effects, and p53-independent apoptosis. Polyamines, specifically spermine and spermidine,
are essential for thymidine kinase production, DNA synthesis, and cell proliferation.
(NCI04);
UNII : OD5Q0L447W;
InChIKey : MXWHMTNPTTVWDM-NXOFHUPFSA-N;
CAS number : 459-86-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 459-86-9
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G-SRS /a ;
Drug name : Zyrkamine; Methyl-GAG;
Molecule name : DRG-0223;
Chemical formula : C5H12N8;
NSC code : 32946;
Codes from synonyms : NSC0032946; 50544;
Origin ID : C661;
UMLS CUI : C0026251;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_salt_form
- is_component_of_chemotherapy_regimen
- is_free_acid_or_base_form_of
