JAK2 Inhibitor AZD1480

Preferred Label : JAK2 Inhibitor AZD1480;

NCIt related terms : AZD-1480;

NCIt definition : An orally bioavailable inhibitor of Janus-associated kinase 2 (JAK2) with potential antineoplastic activity. JAK2 inhibitor AZD1480 inhibits JAK2 activation, leading to the inhibition of the JAK/STAT (signal transducer and activator of transcription) signaling including activation of STAT3. This may lead to induction of tumor cell apoptosis and a decrease in cellular proliferation. JAK2, often upregulated or mutated in a variety of cancer cells, mediates STAT3 activation and plays a key role in tumor cell proliferation and survival.;

UNII : KL2Z2TLF01;

CAS number : 935666-88-9;

Molecule name : AZD1480;

Détails

Origin ID

C91394;

UMLS CUI

C2745423;

CISMeF manual mappings
- AZD 1480 [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- AZD 1480 [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- AZD 1480 [MeSH concept]
- AZD 1480 [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Tyrosine-Protein Kinase JAK2 [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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