NCIt definition : An orally bioavailable inhibitor of Janus-associated kinase 2 (JAK2) with potential
antineoplastic activity. JAK2 inhibitor AZD1480 inhibits JAK2 activation, leading
to the inhibition of the JAK/STAT (signal transducer and activator of transcription)
signaling including activation of STAT3. This may lead to induction of tumor cell
apoptosis and a decrease in cellular proliferation. JAK2, often upregulated or mutated
in a variety of cancer cells, mediates STAT3 activation and plays a key role in tumor
cell proliferation and survival.;
UNII : KL2Z2TLF01;
CAS number : 935666-88-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 935666-88-9
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;