Preferred Label : Formation of Ketone Bodies from Acetyl-CoA Pathway;
NCIt related terms : Formation of Ketone Bodies from Acetyl-CoA;
Alternative definition : BIOCARTA: The acetyl-CoA produced by mitochondrial beta-oxidation of fatty acids enters
the Kreb's cycle to produce energy, but that is not the only fate of acetyl-CoA. In
liver mitochondria, some acetyl-CoA is converted to acetoacetate, beta-hydroxybutyrate,
and acetone, collectively called ketone bodies. Ketone bodies are transported to other
tissues such as brain, muscle or heart where they are converted back to acetyl-CoA
to serve as an energy source. The brain normally uses only glucose for energy, but
during starvation ketone bodies can become the main energy source for the brain. In
the metabolic condition called ketosis, ketone bodies are produced faster than they
are consumed by tissues and the smell of acetone can be detected on a person's breath.
The smell of acetone is one indication that a person may have diabetes. The consumption
of high-fat/low carbohydrate diets has been used as a weight loss program by many,
intentionally inducing ketosis to consume fat stores, but these ketogenic diets can
cause unwanted side effects related to increased urea production resulting from protein
intake and risk of heart disease from increased cholesterol and fat intake. (This
definition may be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : ketonebodiesPathway;
Origin ID : C91328;
UMLS CUI : C2984168;
Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element
