Hydroxymethylglutaryl-CoA Synthase, Cytoplasmic

Preferred Label : Hydroxymethylglutaryl-CoA Synthase, Cytoplasmic;

NCIt synonyms : HMG-CoA Synthase; EC 2.3.3.10; HMG-CoA Synthase 1; HMGCS1; 3-Hydroxy-3-Methylglutaryl Coenzyme A Synthase; 3-Hydroxy-3-Methylglutaryl-Co A Synthase 1;

NCIt definition : Hydroxymethylglutaryl-CoA synthase, cytoplasmic (520 aa, 57 kDa) is encoded by the human HMGCS1 gene. This protein plays a role in the condensation of acetyl-Coenzyme A with acetoacetyl-CoA to form hydroxymethylglutaryl-CoA (HMG-CoA).;

NCI Metathesaurus CUI : CL775588;

Details

Origin ID

C179337;

UMLS CUI

C4507959;

Automatic exact mappings (from CISMeF team)
- 3-hydroxy-3-methylglutaryl-coa synthase 1 [OMIM gene]
- Hydroxymethylglutaryl-CoA synthase [MeSH Descriptor]
OMIM relation
- 3-hydroxy-3-methylglutaryl-coa synthase 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- HMGCS1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- HMGCS1 Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Butanoate Metabolism Pathway [NCIt concept]
- FOXA2 and FOXA3 Transcription Factor Signaling Pathway [NCIt concept]
- Formation of Ketone Bodies from Acetyl-CoA Pathway [NCIt concept]
- Synthesis and Degradation of Ketone Bodies Pathway [NCIt concept]
- Terpenoid Biosynthesis Pathway [NCIt concept]
- Valine, Leucine and Isoleucine Degradation Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cholesterol Homeostasis [NCIt concept]
- Nucleotide Metabolic Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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