Preferred Label : T Cell Receptor and CD3 Complex Signaling Pathway;
NCIt synonyms : T Cell Receptor and CD3 Complex Pathway;
NCIt related terms : T Cell Receptor and CD3 Complex;
Alternative definition : BIOCARTA: The T cell receptor is a cell-surface receptor that recognizes specific
antigen to stimulate the T cell response to that antigen. The T cell receptor complex
of transmembrane proteins includes the T cell receptor that recognizes antigen and
a set of proteins called CD3 involved in signal transduction. CD3 associated with
the T cell receptor includes six polypeptides arranged in three dimers that recruit
and activate protein kinases to signal the activation of T cell receptor by bound
antigen through recruitment and activation of protein kinases (see T Cell Receptor
Signaling Pathway). T cell receptors only recognize antigen on the surface of other
cells, not antigen in solution, by requiring antigen to be bound to MHC proteins on
the surface of other cells to be recognized. Cytotoxic T cells recognize antigen bound
to MHC I on the surface of other cells and helper T cells recognize antigen bound
to MHC II on antigen-presenting cells. CD4 (helper T cells) and CD8 (cytotoxic T cells)
are cofactors in MHC recognition. Recombination in immature T cells of the genes for
the alpha and beta T cell receptor subunits creates a huge variety of variable regions
involved in antigen recognition resulting in many antigen specificities in the population
of immature T cells. Some T cells called gamma/delta cells express T cell receptor
composed of gamma and delta subunits rather than alpha/beta subunits. When the T cell
receptor on a cell interacts with antigen in the proper context, that cell is stimulated
to become activated and proliferate, in a process known as clonal selection. The recombination
of T cell receptor genes and clonal selection of cells that bind specific antigen
is very similar to the B cell process that creates immunoglobulins and clonal selection
of B cells that bind antigen. (This definition may be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_tcrmolecule;
Origin ID : C91304;
UMLS CUI : C2984145;
Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element
