Deoxyhypusine Hydroxylase

Preferred Label : Deoxyhypusine Hydroxylase;

NCIt synonyms : hDOHH; Deoxyhypusine Monooxygenase; Deoxyhypusine Dioxygenase; EC 1.14.99.29; HEAT-Like Repeat-Containing Protein 1; DOHH;

NCIt definition : Deoxyhypusine hydroxylase (302 aa, 33 kDa) is encoded by the human DOHH gene. This protein is involved in the hydroxylation of lysine to form hypusine.;

NCIt note : Deoxyhypusine hydroxylase catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eukaryotic translation initiation factor 5A-1. (UniProt);

Details

Origin ID

C91281;

UMLS CUI

C5441767;

Currated CISMeF NLP mapping
- Deoxyhypusine monooxygenase (substance) [SNOMED CT concept]
- deoxyhypusine hydroxylase [MeSH concept]
- deoxyhypusine hydroxylase [MeSH Supplementary Concept]
OMIM relation
- Deoxyhypusine hydroxylase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Deoxyhypusine monooxygenase (substance) [SNOMED CT concept]
- deoxyhypusine hydroxylase [MeSH concept]
- deoxyhypusine hydroxylase [MeSH Supplementary Concept]
gene_encodes_gene_product
- DOHH Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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