NCIt definition : An orally bioavailable, small molecule inhibitor of vascular endothelial growth factor
(VEGF) synthesis with potential antiangiogenesis and antineoplastic activities. Emvododstat
targets post-transcriptionally by selectively binding the 5'- and 3'-untranslated
regions (UTR) of VEGF messenger RNA (mRNA), thereby preventing translation of VEGF.
This inhibits VEGF protein production and decreases its levels in the tumor and bloodstream.
In turn, this may result in the inhibition of migration, proliferation and survival
of endothelial cells, microvessel formation, the inhibition of tumor cell proliferation,
and eventually the induction of tumor cell death. VEGFs are upregulated in a variety
of tumor cell types and play key roles during angiogenesis. In addition, emvododstat
may enhance the antitumor activity of other chemotherapeutic agents.;