" /> Balixafortide - CISMeF





Preferred Label : Balixafortide;

NCIt synonyms : Ala-cys-ser-ala-pro-arg-tyr-cys-tyr-gln-lys-pro-pro-tyr-his Cyclic (2- 9)-disulfide;

NCIt definition : An orally bioavailable inhibitor of CXC chemokine receptor 4 (CXCR4) with receptor binding and hematopoietic stem cell-mobilization activities. Balixafortide binds to the chemokine receptor CXCR4, thereby preventing the binding of stromal derived factor-1 (SDF-1 or CXCL12) to the CXCR4 receptor and subsequent receptor activation. This may induce the mobilization of hematopoietic stem and progenitor cells from the bone marrow into blood. CXCR4, a chemokine receptor belonging to the G protein-coupled receptor (GPCR) gene family, plays an important role in chemotaxis and angiogenesis and is upregulated in several tumor cell types; CXCL12/CXCR4 interaction induces retention of hematopoietic cells in the bone marrow.;

UNII : PRC974M49B;

CAS number : 1051366-32-5;

Molecule name : POL6326;

NCI Metathesaurus CUI : CL421480;

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Keyword's position in hierarchy(ies) : arborescence

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08/05/2025


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