Ascrinvacumab - CISMeF

Preferred Label : Ascrinvacumab;

NCIt synonyms : Anti-Activin Receptor-like Kinase 1 Monoclonal Antibody PF-03446962; Anti-ALK-1 Monoclonal Antibody GT90001; Anti-Activin Receptor-like Kinase-1 Monoclonal Antibody GT90001;

NCIt definition : A human immunoglobulin G2 (IgG2) monoclonal antibody against activin receptor-like kinase-1 (ALK-1; ALK1), with potential anti-angiogenic and antineoplastic activities. Upon administration, ascrinvacumab targets and binds to ALK-1, and prevents ALK-1 activation by its ligands bone morphogenetic protein 9 (BMP) 9 and BMP10. This prevents ALK-1-mediated endothelial cell signaling and the activation of transforming growth factor-beta (TGF-beta)/TGF-beta receptor I (ALK-5) signaling. This inhibits tumor blood vessel growth, reduces blood flow and angiogenesis and leads to an inhibition of tumor cell proliferation and modulation of the tumor microenvironment (TME). ALK-1, a member of the transforming growth factor beta (TGF-b) type I receptor family, is overexpressed on endothelial cells in a variety of tumor cell types and increases endothelial cell proliferation and migration.;

UNII : 716FQ5REVO;

CAS number : 1463459-96-2;

Molecule name : PF-03446962; GT-90001; GT 90001; PF 03446962;

Details

Origin ID

C91073;

UMLS CUI

C4519598;

Automatic exact mappings (from CISMeF team)
- ascrinvacumab [MeSH concept]
Currated CISMeF NLP mapping
- ascrinvacumab [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ascrinvacumab [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Serine/Threonine-Protein Kinase Receptor R3 [NCIt concept]

Keyword's position in hierarchy(ies) :

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