Preferred Label : Hsp90 Inhibitor SNX-5422 Mesylate;
NCIt related terms : SNX-5422; SNX-5422 mesylate;
NCIt definition : The orally bioavailable mesylate salt of a synthetic prodrug targeting the human heat-shock
protein 90 (Hsp90) with potential antineoplastic activity. Although the mechanism
of action remains to be fully elucidated, Hsp90 inhibitor SNX-5422 is rapidly converted
to SNX-2112, which accumulates more readily in tumors relative to normal tissues.
SNX-2112 inhibits Hsp90, which may result in the proteasomal degradation of oncogenic
client proteins, including HER2/ERBB2, and the inhibition of tumor cell proliferation.
Hsp90 is a molecular chaperone that plays a key role in the conformational maturation
of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated
p53, as well as many other molecules that are important in cell cycle regulation or
immune responses.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. SNX-5422 mesylate
blocks a protein needed for cells to grow and may kill cancer cells. It is a type
of heat shock protein 90 inhibitor.;
UNII : K3BO8V06RM;
InChIKey : NVGFSTMGRRADRG-IOJSEOPQSA-N;
CAS number : 1173111-67-5;
Codes from synonyms : CDR0000600462; CDR0000601200;
Origin ID : C91068;
UMLS CUI : C4552071;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
