Preferred Label : Topoisomerase I Inhibitor LMP400;
NCIt related terms : LMP400;
NCIt definition : An indenoisoquinoline and non-camptothecin inhibitor of topoisomerase I (Top I) with
potential antineoplastic activity. Topoisomerase I inhibitor LMP400 binds to the topoisomerase
I-DNA covalent cleavage complexes, and inhibits repair of single-strand DNA breaks,
DNA replication, and tumor cell growth in susceptible tumor cell populations. Compared
to camptothecins, indenoisoquinolines are chemically stable, produce stable Top I-DNA
cleavage complexes, induce unique DNA cleavage sites and appear more resistant to
multidrug efflux pumps.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. It blocks certain
enzymes that break and rejoin DNA strands. These enzymes are needed for cells to divide
and grow. Blocking them may cause cancer cells to die. LMP400 also helps anticancer
drugs kill cancers that are resistant to some other drugs. LMP400 is a type of indenoisoquinoline
and a type of topoisomerase inhibitor.;