Preferred Label : STAT3 Inhibitor OPB-31121;
NCIt definition : An orally bioavailable inhibitor of signal transducer and activator of transcription
3 (STAT3), with potential antineoplastic activity. OPB-31121 inhibits the phosphorylation
of STAT3, which prevents binding of STAT3 to DNA sequences on a variety of STAT3-responsive
promoters and may result in the inhibition of STAT3-mediated transcription and, potentially,
the inhibition of tumor cell proliferation. STAT3 is constitutively activated in a
variety of cancers, contributing to the loss of cell growth control and neoplastic
transformation.;
Molecule name : OPB-31121;
NCI Metathesaurus CUI : CL376190;
Origin ID : C90588;
UMLS CUI : C2983787;
Semantic type(s)
- concept_is_in_subset
- has_target
