Preferred Label : JAK2 Inhibitor XL019;
NCIt related terms : XL-019;
NCIt definition : An orally bioavailable inhibitor of Janus-associated kinase 2 (JAK2) with potential
antineoplastic activity. XL019 inhibits the activation of JAK2 as well as the mutated
form JAK2V617F, which may result in the inhibition of the JAK-STAT signaling pathway
and may induce apoptosis. The JAK2 mutated form JAK2V617F has a valine-to-phenylalanine
modification at position 617 and plays a key role in tumor cell proliferation and
survival.;
UNII : 4L1AM42NVA;
CAS number : 945755-56-6;
Molecule name : XL019;
NCI Metathesaurus CUI : CL416257;
Origin ID : C90573;
UMLS CUI : C2983773;
Semantic type(s)
- concept_is_in_subset
- has_target
