Preferred Label : Briciclib Sodium;
NCIt synonyms : Phenol, 2-Methoxy-5-((((1E)-2-(2,4,6-trimethoxyphenyl)ethenyl)sulfonyl)methyl)-, 1-(Dihydrogen
Phosphate), Sodium Salt (1:2); 2-Methoxy-5-(((2-(2,4,6-trimethoxyphenyl)ethenyl)sulfonyl)methyl)phenyl Disodium Phosphate;
NCIt definition : A benzyl styryl sulfone analog, and a disodium phosphate ester prodrug of ON 013100,
with potential antineoplastic activity. Upon hydrolysis, briciclib is converted to
ON 013100, which blocks cyclin D mRNA translation and decreases protein expression
of cyclin D. This may induce cell cycle arrest and apoptosis in cancer cells overexpressing
cyclin D and eventually decrease tumor cell proliferation. This agent may exhibit
synergistic antitumor activity in combination with other chemotherapeutic agents.
Cyclin D, a member of the cyclin family of cell cycle regulators, plays a key role
in cell cycle division and is often overexpressed in a variety of hematologic and
solid tumors and is correlated with poor prognosis.;
UNII : 7C9N0VM8NR;
InChIKey : MIBWXNAYNGADJD-MIIBGCIDSA-L;
CAS number : 865784-01-6;
Molecule name : ON 013105;
Origin ID : C90541;
UMLS CUI : C3899909;
Semantic type(s)
- concept_is_in_subset
- has_target
